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Ausgewählte Publikationen

Ball NJ, Nicastro G, Dutta M, Pollard DJ, Goldstone DC, Sanz-Ramos M, Ramos A, Müllers E, Stirnnagel K, Stanke N, Lindemann D, Stoye JP, Taylor WR, Rosenthal PB, Taylor IA. Structure of a Spumaretrovirus Gag Central Domain Reveals an Ancient Retroviral Capsid. PLoS Pathog. 2016 Nov 9;12(11):e1005981.


Hamann MV, Lindemann D. Foamy Virus Protein-Nucleic Acid Interactions during Particle Morphogenesis. Viruses. 2016 Aug 30;8(9). pii: E243.


Zurnic I, Hütter S, Rzeha U, Stanke N, Reh J, Müllers E, Hamann MV, Kern T, Gerresheim GK, Lindel F, Serrao E, Lesbats P, Engelman AN, Cherepanov P, Lindemann D. Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. PLoS Pathog. 2016 Aug 31;12(8):e1005860. eCollection 2016 Aug. Erratum in: PLoS Pathog. 2016 Oct 10;12 (10 ):e1005956.

 

Effantin G, Estrozi LF, Aschman N, Renesto P, Stanke N, Lindemann D, Schoehn G, Weissenhorn W. Cryo-electron Microscopy Structure of the Native Prototype Foamy Virus Glycoprotein and Virus Architecture. PLoS Pathog. 2016 Jul 11;12(7):e1005721.


Sweeney NP, Regan C, Liu J, Galleu A, Dazzi F, Lindemann D, Rupar CA, McClure MO. Rapid and Efficient Stable Gene Transfer to Mesenchymal Stromal Cells Using a Modified Foamy Virus Vector. Mol Ther. 2016 Aug;24(7):1227-36.


Bähr A, Singer A, Hain A, Vasudevan AA, Schilling M, Reh J, Riess M, Panitz S, Serrano V, Schweizer M, König R, Chanda S, Häussinger D, Kochs G, Lindemann D, Münk C. Interferon but not MxB inhibits foamy retroviruses. Virology. 2016 Jan 15;488:51-60.


Mende N, Kuchen EE, Lesche M, Grinenko T, Kokkaliaris KD, Hanenberg H, Lindemann D, Dahl A, Platz A, Höfer T, Calegari F, Waskow C. CCND1-CDK4-mediated cell cycle progression provides a competitive advantage for human hematopoietic stem cells in vivo. J Exp Med. 2015 Jul 27;212(8):1171-83.

 

Maskell DP, Renault L, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann D, Engelman AN, Costa A, Cherepanov P. Structural basis for retroviral integration into nucleosomes. Nature. 2015 Jul 16;523(7560):366-9.

 

Heymann MC, Winkler S, Luksch H, Flecks S, Ritter L, Franke M, Ruß S, Özen S, Yilmaz E, Klein C, Kallinich T, Lindemann D, Brenner S, Ganser G, Roesler J, Rösen-Wolff A, Hofmann SR. Human procaspase-1 variants with decreased enzymatic activity are associated with febrile episodes and may contribute to inflammation via RIP2 and NFkB signaling. J Immunol. 2014 May 1;192(9):4379-85.

 

Gramberg T, Kahle T, Bloch N, Wittmann S, Müllers E, Daddacha W, Hofmann H, Kim B, Lindemann D, Landau NR. Restriction of diverse retroviruses by SAMHD1. Retrovirology 2013; 10:26.

 

Behrendt R, Schumann T, Gerbaulet A, Nguyen LA, Schubert N, Alexopoulou D, Berka U, Lienenklaus S, Peschke K, Gibbert K, Wittmann S, Lindemann D, Weiss S, Dahl A, Naumann R, Dittmer U, Kim B, Mueller W, Gramberg T, Roers A. Mouse SAMHD1 has antiretroviral activity and suppresses a spontaneous cell-intrinsic antiviral response. Cell Rep. 2013 Aug 29;4(4):689-96.

 

Hütter S, Müllers E, Stanke N, Reh J, Lindemann D. Prototype Foamy Virus Protease Activity Is Essential for Intraparticle Reverse Transcription Initiation but Not Absolutely Required for Uncoating upon Host Cell Entry. J Virol 2013; 87(6):3163-76.

 

Swiersy A, Wiek C, Zentgraf H, Lindemann D. Characterization and manipulation of foamy virus membrane interactions. Cell Microbiol 2013; 15(2):227-36.

 

Stirnnagel K, Schupp D, Dupont A, Kudryavtsev V, Reh J, Müllers E, Lamb DC, Lindemann D. Differential pH-dependent cellular uptake pathways among foamy viruses elucidated using dual-colored fluorescent particles. Retrovirology 2012; 9:71.

 

Feldmann A, Arndt C, Töpfer K, Stamova S, Krone F, Cartellieri M, Koristka S, Michalk I, Lindemann D, Schmitz M, Temme A, Bornhäuser M, Ehninger G, Bachmann M. Novel humanized and highly efficient bispecific antibodies mediate killing of prostate stem cell antigen-expressing tumor cells by CD8+ and CD4+ T cells. J Immunol 2012; 189(6):3249-59.

 

Plochmann K, Horn A, Gschmack E, Armbruster N, Krieg J, Wiktorowicz T, Weber C, Stirnnagel K, Lindemann D, Rethwilm A, Scheller C. Heparan sulfate is an attachment factor for foamy virus entry. J Virol 2012; 86(18):10028-35.

 

Valtink M, Knels L, Stanke N, Engelmann K, Funk RH, Lindemann D. Overexpression of human HMW FGF-2 but not LMW FGF-2 reduces the cytotoxic effect of lentiviral gene transfer in human corneal endothelial cells. Invest Ophthalmol Vis Sci 2012; 53(6):3207-14.

 

Protze S, Khattak S, Poulet C, Lindemann D, Tanaka EM, Ravens U. A new approach to transcription factor screening for reprogramming of fibroblasts to cardiomyocyte-like cells. J Mol Cell Cardiol 2012; 53(3):323-32.

 

Ho YP, Schnabel V, Swiersy A, Stirnnagel K, Lindemann D. A small-molecule-controlled system for efficient pseudotyping of prototype foamy virus vectors. Mol Ther 2012; 20(6):1167-76.

 

Gerl MJ, Sampaio JL, Urban S, Kalvodova L, Verbavatz JM, Binnington B, Lindemann D, Lingwood CA, Shevchenko A, Schroeder C, Simons K. Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane. J Cell Biol 2012; 196(2):213-21.

 

Lindemann D, Rethwilm A. Foamy virus biology and its application for vector development. Viruses 2011; 3(5):561-85.

 

Swiersy A, Wiek C, Reh J, Zentgraf H, Lindemann D. Orthoretroviral-like prototype foamy virus Gag-Pol expression is compatible with viral replication. Retrovirology 2011; 8:66.

 

Valtink M, Stanke N, Knels L, Engelmann K, Funk RH, Lindemann D. Pseudotyping and culture conditions affect efficiency and cytotoxicity of retroviral gene transfer to human corneal endothelial cells. Invest Ophthalmol Vis Sci 2011; 52(9):6807-13.

 

Müllers E, Stirnnagel K, Kaulfuss S, Lindemann D. Prototype foamy virus gag nuclear localization: a novel pathway among retroviruses. J Virol 2011; 85(18):9276-85.

 

Frentzen A, Hüging K, Bitzegeio J, Friesland M, Haid S, Gentzsch J, Hoffmann M, Lindemann D, Zimmer G, Zielecki F, Weber F, Steinmann E, Pietschmann T. Completion of hepatitis C virus replication cycle in heterokaryons excludes dominant restrictions in human non-liver and mouse liver cell lines. PLoS Pathog 2011; 7(4):e1002029.

 

Artegiani B, Lindemann D, Calegari F. Overexpression of cdk4 and cyclinD1 triggers greater expansion of neural stem cells in the adult mouse brain. J Exp Med 2011; 208(5):937-48.

 

Matthes D, Wiktorowicz T, Zahn J, Bodem J, Stanke N, Lindemann D, Rethwilm A. Basic residues in the foamy virus Gag protein. J Virol 2011; 85(8):3986-95.

 

Müllers E, Uhlig T, Stirnnagel K, Fiebig U, Zentgraf H, Lindemann D. Novel functions of Prototype Foamy Virus Gag GR boxes in reverse transcription and particle morphogenesis. J Virol 2011; 85(4):1452-63.

 

Stirnnagel K, Lüftenegger D, Stange A, Swiersy A, Müllers E, Reh J, Stanke N, Große A, Chiantia S, Keller H, Schwille P, Hanenberg H, Zentgraf H, Lindemann D. Analysis of Prototype Foamy Virus particle-host cell interaction with autofluorescent retroviral particles. Retrovirology 2010; 7(1):45.

 

Yap MW*, Lindemann D*, Stanke N, Reh J, Westphal D, Hanenberg H, Ohkura S, Stoye JP. Restriction of Foamy Viruses by Primate Trim5a. J Virol 2008; 82(11):5429-5439. (*equal contribution)

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Teilprojektleiter:

Prof. Dr. phil.
Dirk Lindemann
(1. Förderphase)

Institut für Virologie
Tel.: 0351-458 6210
Email: dirk.lindemann@
tu-dresden.de