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Subproject T

Technology platform for fluorescence correlation spectroscopy

This project provides a technology platform for fluorescence correlation spectroscopy (FCS) and fluorescence cross-correlation spectroscopy (FCCS) to the Clinical Research Group. FCS and FCCS are biophysical methods for the assessment of quantitative parameters of biomolecular systems and can be used to determine concentrations, mobilities and interactions of fluorescently labeled molecules on a single molecule level in real time. FCS/FCCS is applied to aqueous environments such as living cells and therefore allows the analysis of the in-situ biochemistry. In contrast to other fluorescence based techniques such as co-localization and fluorescence resonance energy transfer (FRET), FCCS is more specific and less dependent on the exact positioning of the fluorescent labels within molecules. In addition to providing FCS/FCCS support on a turnkey instrument of the Dresden technology platform, this project aims to develop the methodological basis for implementation of three color (three components) applications in cells.






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Project leader:

Prof. Dr. Jochen Guck

Biotechnologisches Zentrum
Tel.: 0351-463 40330
Email: jochen.guck@

Sekretariat: Heike Neumann
Tel.: 0351-463 40349
Email: heike.neumann@