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Subproject 5

The role of defects in nucleic acid metabolism for the pathogenesis of cutaneous autoimmune diseases

Lupus erythematosus is a multifactorial autoimmune disease which is caused by both genetic and environmental factors such as UV-radiation. Mutations in the gene encoding the intracellular nuclease TREX1 are the cause of familial chilblain lupus and have also been described in patients with multifactorial systemic lupus erythematosus. The aim of the project is to investigate the role of Trex1 and other nucleases in the pathogenesis of cutaneous lupus erythematosus. Besides the clinical investigation of patients and the immunohistological characterisation of lesional biopsies, we will focus on the impact of UV-radiation on the induction of inflammatory responses in primary cells of lupus patients and in animal models with nuclease deficiency. 

 

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Project leader:

Claudia Günther

Priv.-Doz. Dr. med.
Claudia Günther

Klinik und Poliklinik
für Dermatologie
Tel.: 0351-458 2344
Email: claudia.guenther@
uniklinikum-dresden.de