Clinical Research Group 249
The innate immune system plays a central role in the defense against microorganisms and in inflammatory processes. Focus of the Clinical Research Group 249 "Defects of the innate immune system in autoinflammatory and autoimmune diseases" is the identification of new pathophysiological mechanisms of disorders associated with abnormalities of the innate immune system. The investigated phenotypic spectrum includes periodic fever syndromes, cutaneous and systemic forms of lupus erythematosus and Aicardi-Goutières syndrome, an autoimmune encephalopathy. The genetic changes associated with these diseases point to previously unknown pathogenic mechanisms within the innate immune system.
On the basis of genetically defined autoinflammatory and autoimmune diseases, we will investigate the consequences of perturbations in pathways related to inflammasome formation and nucleic acid metabolism at the molecular and cellular level as well as in animal models and in patients. Our goal is to provide novel insights into the molecular pathogenesis of defects of the innate immune system and to facilitate the translation of basic research findings into clinically relevant concepts.
The Clinical Research Group 249 is an interdisciplinary research network and is funded by the Deutsche Forschungsgemeinschaft (DFG).